220991-20-8|Lumiracoxib|2-(2-((2-chloro-6-fluorophenyl)amino)-5-methylphenyl)acetic acid|-范德生物科技公司

Lumiracoxib

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names：
2-(2-((2-chloro-6-fluorophenyl)amino)-5-methylphenyl)acetic acid
CAS号：
220991-20-8
MDL Number：
MF(分子式)： C15H13ClFNO2 MW(分子量)： 293.7224
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	Lumiracoxib
英文别名	CGS-35189; CGS 35189; CGS35189; COX-189; COX189; COX 189; Lumiracoxib; trade name Prexige.
CAS号	220991-20-8
SMILES	O=C(O)CC1=CC(C)=CC=C1NC2=C(F)C=CC=C2Cl
Inchi	InChI=1S/C15H13ClFNO2/c1-9-5-6-13(10(7-9)8-14(19)20)18-15-11(16)3-2-4-12(15)17/h2-7,18H,8H2,1H3,(H,19,20)
InchiKey	KHPKQFYUPIUARC-UHFFFAOYSA-N
分子式 Formula	C15H13ClFNO2
分子量 Molecular Weight	293.7224
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Lumiracoxib(CAS:220991-20-8):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Lumiracoxib, also known as CGS 35189 and COX 189, is a COX-2 selective inhibitor non-steroidal anti-inflammatory drug, manufactured by Novartis and still sold in few countries, including Mexico, Ecuador and the Dominican Republic, under the trade name Prexige. Since its original approval, lumiracoxib has been withdrawn from the market in several countries, mostly due to its potential for causing liver failure (sometimes requiring liver transplantation). It has never been approved for use in the United States.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Silva RC, Riera R, Saconato H. Lumiracoxib for acute postoperative dental pain: a systematic review of randomized clinical trials. Sao Paulo Med J. 2011;129(5):335-45. Review. PubMed PMID: 22069133.

[2]Roy YM, Derry S, Moore RA. Single dose oral lumiracoxib for postoperative pain in adults. Cochrane Database Syst Rev. 2010 Jul 7;(7):CD006865. doi: 10.1002/14651858.CD006865.pub2. Review. PubMed PMID: 20614451; PubMed Central PMCID: PMC4164453.

[3] Chen YF, Jobanputra P, Barton P, Bryan S, Fry-Smith A, Harris G, Taylor RS. Cyclooxygenase-2 selective non-steroidal anti-inflammatory drugs (etodolac, meloxicam, celecoxib, rofecoxib, etoricoxib, valdecoxib and lumiracoxib) for osteoarthritis and rheumatoid arthritis: a systematic review and economic evaluation. Health Technol Assess. 2008 Apr;12(11):1-278, iii. Review. PubMed PMID: 18405470.

[4] Roy YM, Derry S, Moore RA. Single dose oral lumiracoxib for postoperative pain. Cochrane Database Syst Rev. 2007 Oct 17;(4):CD006865. Review. Update in: Cochrane Database Syst Rev. 2010;(7):CD006865. PubMed PMID: 17943921; PubMed Central PMCID: PMC4158423.

[5] Yuan Y, Hunt RH. Global gastrointestinal safety profile of etoricoxib and lumiracoxib. Curr Pharm Des. 2007;13(22):2237-47. Review. PubMed PMID: 17691997.

6: Bannwarth B, Bérenbaum F. Lumiracoxib in the management of osteoarthritis and acute pain. Expert Opin Pharmacother. 2007 Jul;8(10):1551-64. Review. PubMed PMID: 17661736.7: Buvanendran A, Barkin R. Lumiracoxib. Drugs Today (Barc). 2007 Mar;43(3):137-47. Review. PubMed PMID: 17380211.8: Rordorf CM, Choi L, Marshall P, Mangold JB. Clinical pharmacology of lumiracoxib: a selective cyclo-oxygenase-2 inhibitor. Clin Pharmacokinet. 2005;44(12):1247-66. Review. PubMed PMID: 16372823.9: Matchaba P, Gitton X, Krammer G, Ehrsam E, Sloan VS, Olson M, Mellein B, Hoexter G, Orloff J, Garaud JJ. Cardiovascular safety of lumiracoxib: a meta-analysis of all randomized controlled trials > or =1 week and up to 1 year in duration of patients with osteoarthritis and rheumatoid arthritis. Clin Ther. 2005 Aug;27(8):1196-214. Review. PubMed PMID: 16199245.10: Bannwarth B, Berenbaum F. Clinical pharmacology of lumiracoxib, a second-generation cyclooxygenase 2 selective inhibitor. Expert Opin Investig Drugs. 2005 Apr;14(4):521-33. Review. PubMed PMID: 15882125.1

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