79516-68-0|Levocabastine|(3S,4R)-1-[4-cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenylpiperidine-4-carboxylic acid|-范德生物科技公司

Levocabastine

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names：
(3S,4R)-1-[4-cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenylpiperidine-4-carboxylic acid
CAS号：
79516-68-0
MDL Number：
MF(分子式)： C26H29FN2O2 MW(分子量)： 420.5191
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	Levocabastine
英文别名	Levocabastine, Livostin, Bilina
CAS号	79516-68-0
SMILES	O=C([C@@]1(C2=CC=CC=C2)[C@H](C)CN(C3CCC(C4=CC=C(F)C=C4)(C#N)CC3)CC1)O
Inchi	InChI=1S/C26H29FN2O2/c1-19-17-29(16-15-26(19,24(30)31)21-5-3-2-4-6-21)23-11-13-25(18-28,14-12-23)20-7-9-22(27)10-8-20/h2-10,19,23H,11-17H2,1H3,(H,30,31)/t19-,23?,25?,26-/m1/s1
InchiKey	ZCGOMHNNNFPNMX-YHYDXASRSA-N
分子式 Formula	C26H29FN2O2
分子量 Molecular Weight	420.5191
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Levocabastine(CAS:79516-68-0):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Levocabastine is a selective second-generation H1 receptor antagonists. It is used for allergic conjunctivitis. As well as acting as an antihistamine, levocabastine has also subsequently been found to act as a potent and selective antagonist for the neurotensin receptor NTS2, and was the first drug used to characterise the different neurotensin subtypes. This has made it a useful tool for the study of this receptor.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Akiyoshi M, Shigeoka T, Torii S, Maki E, Enomoto S, Takahashi H, Hirano F. [Pharmacological and clinical properties of levocabastine hydrochloride (eye drop and nasal spray), a selective H1 antagonist]. Nihon Yakurigaku Zasshi. 2002 Mar;119(3):175-84. Review. Japanese. PubMed PMID: 11915520.

[2]Noble S, McTavish D. Levocabastine. An update of its pharmacology, clinical efficacy and tolerability in the topical treatment of allergic rhinitis and conjunctivitis. Drugs. 1995 Dec;50(6):1032-49. Review. PubMed PMID: 8612470.

[3] Heykants J, Van Peer A, Van de Velde V, Snoeck E, Meuldermans W, Woestenborghs R. The pharmacokinetic properties of topical levocabastine. A review. Clin Pharmacokinet. 1995 Oct;29(4):221-30. Review. PubMed PMID: 8549024.

[4] Bahmer FA. Topical levocabastine--an effective alternative to oral antihistamines in seasonal allergic rhinoconjunctivitis. Clin Exp Allergy. 1995 Mar;25(3):220-7. Review. PubMed PMID: 7788568.

[5] Knight A. The role of levocabastine in the treatment of allergic rhinoconjunctivitis. Br J Clin Pract. 1994 May-Jun;48(3):139-43. Review. PubMed PMID: 7913336.

6: Janssens MM, Vanden Bussche G. Levocabastine: an effective topical treatment of allergic rhinoconjunctivitis. Clin Exp Allergy. 1991 May;21 Suppl

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