28782-42-5|Difenoxin|1-(3-cyano-3,3-diphenylpropyl)-4-phenylpiperidine-4-carboxylic acid|-范德生物科技公司

Difenoxin

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names：
1-(3-cyano-3,3-diphenylpropyl)-4-phenylpiperidine-4-carboxylic acid
CAS号：
28782-42-5
MDL Number：
MF(分子式)： C28H28N2O2 MW(分子量)： 424.53
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	Difenoxin
英文别名	Difenoxin; Diphenoxylic acid; Difenoxinum; Difenoxine; Diphenoxin; Lyspafen
CAS号	28782-42-5
SMILES	C1CN(CCC1(C2=CC=CC=C2)C(=O)O)CCC(C#N)(C3=CC=CC=C3)C4=CC=CC=C4
Inchi	InChI=1S/C28H28N2O2/c29-22-28(24-12-6-2-7-13-24,25-14-8-3-9-15-25)18-21-30-19-16-27(17-20-30,26(31)32)23-10-4-1-5-11-23/h1-15H,16-21H2,(H,31,32)
InchiKey	UFIVBRCCIRTJTN-UHFFFAOYSA-N
分子式 Formula	C28H28N2O2
分子量 Molecular Weight	424.53
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Difenoxin(CAS:28782-42-5):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Difenoxin (Discontinued) (Motofen, R-15403) is a 4-phenylpiperidine derivative that is related to the opioid analgesic drug pethidine (meperidine) and more distantly related to alphaprodine and piritramide, and it is an active metabolite of the anti-diarrhoea drug diphenoxylate. Difenoxin et al. have a high peripheral/central actions ratio, working primarily on various opioid receptors in the intestines. Difenoxin was developed in 1970 in Belgium at Janssen Pharmaceutica. (Source https//en.wikipedia.org/wiki/Difenoxin). Difenoxin is discontinued (DEA controlled substance)
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]De Luca A, Coupar IM. Difenoxin and loperamide: studies on possible mechanisms of intestinal antisecretory action. Naunyn Schmiedebergs Arch Pharmacol. 1993 Feb;347(2):231-7. PubMed PMID: 8386327.

[2]Borzani M, Giovane AM. [Clinical evaluation of the anti-diarrheal activity of C-C2484 (Difenoxin) in pediatrics, in a controlled of patients]. Minerva Pediatr. 1980 Dec 31;32(24):1399-404. Italian. PubMed PMID: 7017369.

[3] Stransky M, Schwarzenbach FH. [Double-blind study of difenoxin hydrochloride among travellers to tropical countries (author's transl)]. Ther Umsch. 1979 Mar;36(3):267-70. German. PubMed PMID: 375457.

[4] Pece H. [Treatment of diarrhea with difenoxin hydrochloride in children (author's transl)]. Arzneimittelforschung. 1979;29(5):849-51. German. PubMed PMID: 582988.

[5] Thurnherr N, Spring P. [Double-blind study on the influence of difenoxin hydrochloride on intestinal passage time in healthy volunteers (author's transl)]. Arzneimittelforschung. 1979;29(3):559-62. German. PubMed PMID: 582746.

6: Bron BA, Krejs GJ, Peter P, Blum AL. The effect of difenoxin on the lower esophageal sphincter pressure in man. Arch Int Pharmacodyn Ther. 1976 Jul;222(1):40-4. PubMed PMID: 984970.7: Huber J, Siegenthaler H. [Difenoxin hydrochloride; a new antidiarrheal agent; preliminary results of cases of chronic diarrhoea (author's transl)]. Schweiz Rundsch Med Prax. 1976 Jan 20;65(3):84-6. German. PubMed PMID: 1257205.8: Eisner M, Shalev E, Amrein R, Ferrat E. [On the mode of action of difenoxin (R 15 403). Part

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