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7803-57-8
  • names:

    Hydrazine Hydrate

  • CAS号:

    7803-57-8

    MDL Number: MFCD00149931
  • MF(分子式): H6N2O MW(分子量): 50.06
  • EINECS:206-114-9 Reaxys Number:
  • Pubchem ID:24654 Brand:BIOFOUNT
水合肼
水合肼(Hydrazine Hydrate,7803-57-8)肼水合物是水合物.它包含肼.
货品编码 规格 纯度 价格 (¥) 现价(¥) 特价(¥) 库存描述 数量 总计 (¥)
HCR207601-10g 10g 97% ¥ 598.50 ¥ 598.50 4-7周
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中文别名 水合肼(7803-57-8);水合腈;含水肼;水合聯胺;一水合肼;单水合肼;含水联氨;肼一水合物;水合肼,一水;一水合水合肼
英文别名 Hydrazine Hydrate(7803-57-8);Hydrazine hydrate; Hydrazine monohydrate; Hydrazinium hydroxide; Hydrazine hydroxide; HYDRAZINE, MONOHYDRATE; Hydrazine, hydrate; hydraziniumhydroxide
CAS号 7803-57-8
SMILES NN.O
Inchi InChI=1S/H4N2.H2O/c1-2;/h1-2H2;1H2
InchiKey IKDUDTNKRLTJSI-UHFFFAOYSA-N
分子式 Formula H6N2O
分子量 Molecular Weight 50.06
闪点 FP 75 °C
熔点 Melting point -52 °C
沸点 Boiling point 120-121 °C
Polarizability极化度 Not available
密度 Density 1.027 g/mL
蒸汽压 Vapor Pressure Not available
溶解度Solubility DMSO (Slightly), Methanol (Slightly)
性状 iquid
储藏条件 Storage conditions Room Temperature
水合肼(Hydrazine Hydrate,7803-57-8)毒理性质:
动物 测试类型 途径 实验摄入量 (标准摄入量) 影响 文献来源
guinea pig LD50 oral 40mg/kg (40mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
Hygiene and Sanitation Vol. 30(7-9), Pg. 191, 1965.
mouse LD50 intraperitoneal 156mg/kg (156mg/kg)   Cancer Research. Vol. 41, Pg. 1469, 1981.
mouse LD50 oral 83mg/kg (83mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

BEHAVIORAL: EXCITEMENT
Hygiene and Sanitation Vol. 30(7-9), Pg. 191, 1965.
rabbit LD50 oral 55mg/kg (55mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
Hygiene and Sanitation Vol. 30(7-9), Pg. 191, 1965.
rat LD50 oral 129mg/kg (129mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

BEHAVIORAL: EXCITEMENT
Hygiene and Sanitation Vol. 30(7-9), Pg. 191, 1965.

Hydrazine Hydrate(7803-57-8)实验注意事项:
1.实验前需戴好防护眼镜,穿戴防护服和口罩,佩戴手套,避免与皮肤接触。
2.实验过程中如遇到有毒或者刺激性物质及有害物质产生,必要时实验操作需要手套箱内完成以免对实验人员造成伤害
3.实验后产生的废弃物需分类存储,并交于专业生物废气物处理公司处理,以免造成环境污染
Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.
Tag:水合肼蒸汽压,水合肼合成,水合肼标准,水合肼应用,水合肼合成,水合肼沸点,水合肼闪点,水合肼用途,水合肼溶解度,水合肼价格,水合肼作用,水合肼结构式,水合肼用处
产品说明 水合肼(7803-57-8)肼水合物是水合物.水合肼包含肼.水合肼溶解度,水合肼MSDS,水合肼结构式详见主页.
IntroductionHydrazine Hydrate(7803-57-8):only use for non-medical purposes in industrial or scientific research, and not for clinical diagnosis and treatment of humans or animals. This product is not medicinal or edible.
Application1
Application2
Application3
Direct Synthesis of Symmetrical Azines from Alcohols and Hydrazine Catalyzed by a Ruthenium Pincer Complex: Effect of Hydrogen Bonding PMID 27990319; ACS catalysis 2016 Dec; 6(12):8415-8419 Name match
Dioxygen in combination with hydrazine: a practical system for degradation of a broad spectrum of toxic organics in water PMID 21752540; Journal of hazardous materials 2011 Sep; 192(3):1186-91 Name ma
[Kinetic mechanism and characteristics researches for hydrazine-based NOx removal at moderate to high temperatures] PMID 23213922; Huan jing ke xue= Huanjing kexue 2012 Aug; 33(8):2901-8 Name matches:
Studies in spiro heterocycles. Part 4(1): Investigation of the reactions of fluorinated 3-aroylmethylene-indol-2-ones with hydrazine and phenylhydrazine and synthesis of spiro [indole-3,3'-pyrazol]-2-
Synthesis and Antibacterial Screening of Some Pyrazole Derivatives Catalyzed by Cetyltrimethylammoniumbromide (CTAB) PMID 32562527; Current organic synthesis 2020 Jun; ?(?): Name matches: phenyl-hydra
1.Microwave assisted synthesis of novel Pyrazole derivatives and their biological evaluation as anti-bacterial agents/PMID 33076806; Combinatorial chemistry & high throughput screening 2020 Oct; ?(?):/Name matches: pyrazole hydrazine hydrate
Abstract:

Aim and objective: Microwave-assisted condensation of acetophenone 1 and aromatic aldehydes 2 gave chalcone analogs 3, which were cyclized to pyrazole derivatives 6a-f via the reaction with hydrazine hydrate and oxalic acid in the presence of the catalytic amount of acetic acid in ethanol.
Materials and methods: The structural features of the synthesized compounds were characterized by melting point, FT-IR, 1H, 13C NMR and elemental analysis.
Results: The antibacterial activities of the synthesized pyrazoles was evaluated against three gram-positive bacteria such as Enterococcus durans, Staphylococcus aureus, Bacillus subtilis and two gram-negative bacteria such as Escherichia coli and Salmonella typhimurium.
Conclusion: All the synthesized pyrazoles showed relatively high antibacterial activity against S. aureus strain and none of them demonstrated antibacterial activity against E. coli.
2.Pyrazole Incorporated New Thiosemicarbazones: Design, Synthesis and Investigation of DPP-4 Inhibitory Effects/PMID 33126761; Molecules (Basel, Switzerland) 2020 Oct; 25(21):/Name matches: pyrazole hydrazine hydrate
Abstract:
Dipeptidyl peptidase-4 (DPP-4) inhibition has been recognized as a promising approach to develop safe and potent antidiabetic agents for the management of type 2 diabetes. In this context, new thiosemicarbazones (2a-o) were prepared efficiently by the reaction of aromatic aldehydes with 4-[4-(1H-pyrazol-1-yl)phenyl]thiosemicarbazide (1), which was obtained via the reaction of 4-(1H-pyrazol-1-yl)phenyl isothiocyanate with hydrazine hydrate. Compounds 2a-o were evaluated for their DPP-4 inhibitory effects based on a convenient fluorescence-based assay. 4-[4-(1H-pyrazol-1-yl)phenyl]-1-(4-bromobenzylidene)thiosemicarbazide (2f) was identified as the most effective DPP-4 inhibitor in this series with an IC50 value of 1.266 ± 0.264 nM when compared with sitagliptin (IC50 = 4.380 ± 0.319 nM). MTT test was carried out to assess the cytotoxic effects of compounds 2a-o on NIH/3T3 mouse embryonic fibroblast (normal) cell line. According to cytotoxicity assay, compound 2f showed cytotoxicity towards NIH/3T3 cell line with an IC50 value higher than 500 µM pointing out its favourable safety profile. Molecular docking studies indicated that compound 2f presented π-π interactions with Arg358 and Tyr666 via pyrazole scaffold and 4-bromophenyl substituent, respectively. Overall, in vitro and in silico studies put emphasis on that compound 2f attracts a great notice as a drug-like DPP-4 inhibitor for further antidiabetic research.
3.Synthesis and Antibacterial Screening of Some Pyrazole Derivatives Catalyzed by Cetyltrimethylammoniumbromide (CTAB)/PMID 32562527; Current organic synthesis 2020 Jun; ?(?):/Name matches: pyrazole hydrazine hydrate
Abstract:

Aims: In this article we have developed an eco-friendly one-pot multi-component reaction methodology was employed for the green synthesis of functionalized pyrazole derivatives viz cyclo-condensation of aromatic aldehydes, ethyl acetoacetate and phenyl hydrazine and/or hydrazine hydrate in the presence of cetyltrimethylammoniumbromide (CTAB) at 90°C temperature in aqueous medium.
Method: In the present protocol we developed a green method for the synthesis of functionalized pyrazole derivatives through one-pot, multi-component cyclo-condensation of aromatic aldehydes, phenyl hydrazine or hydrazine hydrate and ethyl acetoacetate using cetyltrimethylammoniumbromide (CTAB) as a catalyst in water as solvent. Our methodology confers advantages such as short reaction time, atom economy, purification of product without using column chromatographic and hazardous solvent. The reaction is being catalyzed by cetyltrimethylammoniumbromide (CTAB) and thus products are formed under the green reaction conditions.
Results: Initially the reaction of benzaldehyde and phenylhydrazine with ethyl acetoacetate was carried out in water at room temperature in the absence of the catalyst; no product was obtained after 24 h (Table 1 entry 1). When the reaction was carried out using L-proline as catalyst in ethanol at 70°C the yield of product was 20.
Conclusion: This research not only provides a green and efficient method for the synthesis of sulfinic esters but also shows new applications of electrochemistry in organic synthesis. We consider that this green and efficient synthetic protocol used to prepare sulfinic esters will have good applications in future. In conclusion, we have developed successfully a green and efficient one-pot multi-component methodology for the synthesis of substituted pyrazoles using CTAB as a catalyst in water as solvent with excellent yields. Purifications of compounds were achieved without the use of traditional chromatographic procedures. This methodology has advantages of operational simplicity, clean reaction profiles and relatively broad scope which make it more attractive for the diversity oriented synthesis of these heterocyclic libraries. In this methodology we suggest the further alternative possibility for formation of substituted pyrazoles. The compound 7h can be used as an anticancer drug in pharma industry.
Keywords: Green synthesis; Heterocycles; antibacterial screening; cetyltrimethylammoniumbromide (CTAB).; multi-component synthesis; one-pot; pyrazoles.
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